Why Gelora Oral Gel Is Used?
COMPOSITION
Gelora Oral Gel: Every gram of gel contain 20 mg Miconazole BP.
PHARMACOLOGY
The active ingredient, Miconazole, is a synthetic imidazole antifungal with a broad spectrum of action against pathogenic fungi (including yeasts and dermatophytes) and gram-positive bacteria (Staphylococcus and Streptococcus spp). It can work by intrusive with the permeability of fungal compartment membranes. When administered orally, miconazole is incompletely absorbed from the gastrointestinal tract, a maximum plasma level of about 1 μg per ml was achieved after a dose of 1 g per day.
INDICATION
Oral treatment and prevention of fungal infections of the oropharynx and gastrointestinal tract and superinfections caused by gram-positive bacteria.
How do you use Gelora Oral Gel?
DOSAGE AND ADMINISTRATION
Used for Oral Direction: Dose is base on 15 mg/kg/day
- Adults: 1-2 teaspoons of gel four times a day
- Children from 6 years: 1 teaspoon of gel four times a day
- Children aged 2-6 years: 1 teaspoon of gel twice a day
- Infants under 2 years: 1/2 teaspoon of gel twice a day
For localized lesions in the mouth, a small amount of gel can be applied directly to the affected area with a clean finger. For topical treatment of the oropharynx, the gel should be left in the mouth as long as possible. Treatment should be continued for 2 more days after the symptoms disappear. For oral candidiasis, dentures should be removed overnight and coated with gel.
Gelora Oral Gel Use for your mouth
ADVERSE EFFECTS
Nausea and vomiting and diarrhea have been reported occasionally with long-term treatment. In unusual bags, affected by reaction have been reports. There have been isolated reports of hepatitis that have not been proven to be causally related to Miconazole.
CONTRAINDICATION
Miconazole are contraindicated in patients through known sensitivity to the lively drug.
PRECAUTION AND WARNINGS
If concomitant use of Miconazole and anticoagulants is anticipated, the anticoagulant effect should be carefully monitored and titrated. It is advisable to monitor the levels of miconazole and phenytoin if they are taken together. Care must be taken to ensure that the gel does not block the throat, especially in infants and young children. It is therefore advisable to divide the full dose into smaller portions. Observe the patient for possible suffocation.
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Miconazole is generally not highly toxic. In case of accidental overdose, vomiting and diarrhea may occur.
DRUG INTERACTION
Miconazole may inhibit the metabolism of drugs metabolized by the cytochrome P450-3A and CYP-2C9 family. This may result in an increase or prolongation of their e-ects, including side effects. Miconazole Oral Gel must not be used through treatment among the follow drugs: astemizole, terfenadine, triazolam, mizolastine, cisapride, oral midazolam, quinidine, dofetilide, pimozide, HMG-CoA reductase inhibitors metabolised by CYP3A4 such as simvastatin and lovastatin.
USE IN PREGNANCY AND LACTATION
Miconazole has shown no teratogenic effects in animals, but is fetotoxic at high oral doses. The significance of this for men is unknown. Conversely, as with additional imidazoles, Miconazole Oral Gel must be avoid in pregnant women if possible. The potential risks should be weighed against the possible benefits. It’s not well-known whether miconazole is excreted in human being milk. Care must be exercise when prescribe Miconazole Oral Gel to treatment mothers.
STORAGE
Use only on the advice of a registered medical practitioner. Protect from light, store below 30ºC. Keep out of reach of children.
HOW SUPPLIED
Gelora OralGel: Each package has a tube containing 15 g of gel
